Proteins in Deep Eutectic SolventsCancelled

by Andrew Jackson (European Spallation Source)

Monday 17 Nov 2025, 14:30 → 15:30 Europe/Berlin

PH HS 3 (Physics Department)

The preservation of biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. DES are solvents obtained through the complexation of organic compounds, where the interaction between the precursors promotes a depression in the melting point that allows the mixture to remain liquid at room temperature. Moreover, through different combinations of precursors the physicochemical properties of the solvent can be tuned for particular applications. One important characteristic of DES is that they can tolerate the presence of relatively high fractions of water before losing the solvent hydrogen bond network. Thus, the degree of hydration is another tunable parameter available for optimization of the system properties. 

This seminar will discuss deep eutectic solvents in general, the tunability of the solvents, the behaviour of proteins in these solvents, and the effect of hydration on the folding and stability of proteins.

 

References

A. Sanchez-Fernandez, K. J. Edler, T. Arnold, D. A. Venero and A. J. Jackson, Phys. Chem. Chem. Phys., 2017, 19, 8667–8670.

A. Sanchez-Fernandez and A. J. Jackson, in Advances in Botanical Research, Elsevier, 2021, vol. 97, pp. 69–94.

A. Sanchez-Fernandez, M. Basic, J. Xiang, S. Prevost, A. J. Jackson and C. Dicko, J. Am. Chem. Soc., 2022, 144, 23657–23667.