Speaker
Dr
Jan Wollenhaupt
(Helmholtz-Zentrum Berlin)
Description
Macromolecular crystallography (MX) can identify compounds like fragments in their 3D structural context of the protein target, in enhanced through-put. At the MX beamlines at BESSY II, a workflow including dedicated tools, efficient compound libraries and convenient software solutions was established and optimized to provide for efficient screening. Developments like the F2X libraries, the EasyAccess Frame, fspipeline and FragMAXapp elevate the user experience and screening efficiency.
Primary author
Dr
Jan Wollenhaupt
(Helmholtz-Zentrum Berlin)
Co-authors
Mrs
Tatjana Barthel
(Helmholtz-Zentrum Berlin)
Mr
Elmir Jagudin
(MAX IV Laboratory)
Dr
Dirk Wallacher
(Helmholtz-Zentrum Berlin)
Dr
Thomas Hauss
(Helmholtz-Zentrum Berlin)
Dr
Christian Feiler
(Helmholtz-Zentrum Berlin)
Dr
Frank Lennartz
(Helmholtz-Zentrum Berlin)
Dr
Uwe Müller
(Helmholtz-Zentrum Berlin)
Prof.
Andreas Heine
(Institute of Pharmaceutical Chemistry, Philipps-University Marburg)
Dr
Tobias Krojer
(MAX IV Laboratory)
Dr
Manfred Weiss
(Helmholtz-Zentrum Berlin)
