Speaker
Herbert Nar
Description
We determined high resolution structures of human GCH1 and GCH1-GFRP complexes by cryoEM and X-ray crystallography and studied the mechanisms of allosteric regulation by biophysical methods. Inhibition of the enzymatic activity, a drug discovery target in the field of pain disorders, is not a result of hindrance of substrate binding, but rather a consequence of accelerated substrate binding kinetics.
Primary author
Herbert Nar
