Speaker
Daniel Kümmel
Description
The TSC complex is a tumor suppressor regulating cellular growth. We investigated the structure of the TSC1 subunit and identified a coiled-coil domain that binds TSC2, a central helical domain that mediates oligomerization of TSC1 and an N-terminal domain that binds to lipids via a basic interface. These findings reveal a role of TSC1 in by mediating TSC complex membrane recruitment and suggest a function in the formation of TSC supercomplexes.
Primary authors
Katharina Fitzian
Anne Brückner
Reinhard Zech
Patrick Hansmann
Andrea Oeckinghaus
Daniel Kümmel
