Speaker
Dominic Gilzer
Description
Type III secretion systems (T3SS) are bacterial molecular assemblies employed to inject effector proteins in host cells. We present the structure of a T3S export gate with a substrate:chaperone complex. Following a divide-and-conquer strategy, we first determined the structure of the previously uncharacterized substrate:chaperone complex at higher resolution. Our ternary complex marks the first instance where the substrate directly binds to the export gate instead of mediation by the chaperone.
Primary author
Dominic Gilzer
Co-authors
Madeleine Schreiner
Prof.
Hartmut Niemann