Speaker
Mr
Pavel Kats
(Hannover Medical School)
Description
The innate immune sensor 2’-5’-oligoadenylate synthetase (OAS) is among the most promising targets for the development of new antivirals. Here we report the results of kinetic crystallography, mutagenesis, and computational chemistry studies of the OAS1 product release mechanism. These investigations provide new insights into the rate-limiting steps of innate immune signaling, which can help develop allosteric activity modulators of OAS for therapeutic application.
Primary authors
Mr
Pavel Kats
(Hannover Medical School)
Mrs
Xiaoyi Zhou
(Hannover Medical School)
Mr
Ole Zeymer
(Hannover Medical School)
Dr
Jan Lohöfener
(Hannover Medical School)
Dr
Nicola Steinke
(Hannover Medical School)
Mrs
Petra Baruch
(Hannover Medical School)
Prof.
Rune Hartmann
(Aarhus University)
Prof.
Dietmar Manstein
(Hannover Medical School)
Dr
Roman Fedorov
(Hannover Medical School)
