Speaker
Dr
Spyros Chatziefthymiou
(Photon Science, DESY)
Description
Our work focuses on the identification of novel therapeutics against SARS-CoV-2. Using a HT screening approach, compound libraries of approved drugs are used for the discovery of inhibitors for enzymes of the coronavirus replication-transcription complex, followed by the structural determination of the enzyme-inhibitor complexes, revealing their binding mode. This approach is cost efficient, HT compatible, allowing direct identification of potent inhibitors and optimization of beamtime use.
Primary author
Dr
Spyros Chatziefthymiou
(Photon Science, DESY)
Co-authors
Mrs
Maria Kuzikov
(Fraunhofer ITMP ScreeningPort)
Mrs
Sara Afandi
(Helmholtz-Center for Infection Research (HZI))
Dr
Eva Crosas
(ITT DESY )
Dr
Guillaume Pompidor
(Photon Science, DESY )
Dr
Helena Taberman
(Photon Science, DESY )
Mr
Rizvee Ahmed
(Helmholtz-Center for Infection Research (HZI))
Prof.
Björg Windschügel
(Fraunhofer ITMP ScreeningPort)
Prof.
Jörg Labahn
(Forschungszentrum Jülich, Institute of Complex Systems (ICS-6))
Prof.
Michael Kolbe
(Department of Structural Infection Biology, Center for Structural Systems Biology (CSSB), Helmholtz-Center for Infection Research (HZI))
Dr
Johanna Hakanpää
(Photon Science, DESY)
