Speakers
Mr
Gert Weber
(Helmholtz-Zentrum Berlin)
Gottfried Palm
(Universität Greifswald)
Description
The DYW domain, an enzyme for plant RNA editing: Pentatricopeptide repeat (PPR) proteins with a C-terminal DYW domain are responsible for C to U RNA editing in plants. We show that the DYW domain harbors the cytidine deaminase activity by functional data in vitro and structural similarity to distinctly related known cytidine deaminases. A DYW-specific domain regulates the active site sterically via a large-scale conformational change and mechanistically via the Zn-coordination geometry.
Primary author
Mr
Gert Weber
(Helmholtz-Zentrum Berlin)
Co-author
Gottfried Palm
(Universität Greifswald)
