Speaker
Tatjana Barthel
(Helmholtz-Zentrum Berlin)
Description
Crystallographic fragment screening facilitates the identification of weak but efficient small molecules (fragments) while elucidating their binding mode and position. This enables structure-guided optimization of bound fragments into potent modulators. Here, the ~1000-fragment large F2X-Universal Library was screened against a spliceosomal protein-protein complex and resulted in hundreds of hits.
Primary authors
Tatjana Barthel
(Helmholtz-Zentrum Berlin)
Jan Wollenhaupt
(Helmholtz-Zentrum Berlin)
Dr
Gustavo M. A. Lima
Prof.
Markus C. Wahl
(Freie Universität Berlin)
Manfred Weiss
(Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie (HZB-MX))
