MLZ Conference 2021: Neutrons for Life Sciences

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Sessions*

Biological processes

History of FRM II & MLZ

Neutrons in the fight against virus diseases

Welcome of the MLZ directors

Coffee Break

Poster Session

Drug design and delivery

Round Table Discussion & Farewell

Neutron and complementary methods in biology

Life Sciences at Russian Neutron Sources

Biological membranes, surfaces and interfaces

Protein structure, function and dynamics

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Contributions*

64 years of cutting-edge research with neutrons in Garching – How science and politics are intertwined (in session "History of FRM II & MLZ")

ANSTO’s National Deuteration Facility (NDF): A Molecular Deuteration Platform for Characterisation Studies in the Life Sciences (in session "Neutron and complementary methods in biology")

Antibacterial toxin binding to receptor lipids revealed by neutron reflection (in session "Biological membranes, surfaces and interfaces")

Biological Research in Russia: Neutron Research as Essential Part of a Multidisciplinary Approach (in session "Life Sciences at Russian Neutron Sources")

Changes in chromatin organization induced by macromolecules and protein complexes as a possible mechanism for epigenetic regulation (in session "Biological processes")

Combining NMR, SAXS and SANS in integrative structural biology to study dynamics and allostery in protein complexes (in session "Neutron and complementary methods in biology")

Combining small-angle scattering with computational modelling to reveal structural details of Hepatitis B virus (in session "Neutrons in the fight against virus diseases")

Complementary Methods: Molecular Dynamics and SANS (in session "Neutron and complementary methods in biology")

Conformational Changes of IDP under Influence of Guanidinium Chloride: Integrative Approach using X-ray/Neutron Scattering and Single Molecule Spectrosopy (in session "Protein structure, function and dynamics")

DEMAX: the DEuteration and MAcromolecular Xtallization platform of the ESS. (in session "Neutron and complementary methods in biology")

Development of DD Neutron Generator for life sciences and health (in session "Poster Session")

Development of SEC-SANS for life science applications at ISIS TS2 (in session "Protein structure, function and dynamics")

Diffusive-like motions in a solvent free myoglobin-polymer hybrid revealed by neutron scattering and MD simulations (in session "Poster Session")

Dynamical differences between polymorphs of lysozyme amyloid fibrils with different levels of cytotoxicity (in session "Poster Session")

Dynamics of apolipoprotein B-100 assessed by elastic incoherent neutron scattering (in session "Poster Session")

Dynamics of IDP Histatin 5 probed by QENS and compared with simulation (in session "Poster Session")

Effects of glassy matrices on the protein-like dynamical transition of PNIPAM (in session "Poster Session")

Elucidating Melittin selectivity using complex cell membrane models (in session "Poster Session")

Endocytosis across scales (in session "Biological membranes, surfaces and interfaces")

Exploring dynamic processes in biological systems with SPHERES (in session "Poster Session")

Following the diffusive processes during a non-classical protein crystallization via neutron spectroscopy (in session "Poster Session")

Fusion mechanisms of small extracellular vesicles with model membranes (in session "Biological processes")

High-resolution neutron spin echo spectroscopy with the J-NSE “PHOENIX” at MLZ (in session "Poster Session")

High-resolution structure studies of NADH-cytochrome b5 reductase (in session "Protein structure, function and dynamics")

Hydrogen bonding network running through protein kinase investigated by neutron crystallography (in session "Poster Session")

In situ light scattering techniques at neutron instruments at the MLZ (in session "Poster Session")

Influence of NaCl on Phospholipid membranes (in session "Poster Session")

Integrative approach to structure of huge protein complex in Kai-clock protein system (in session "Protein structure, function and dynamics")

JCNS Deuteration Service: What can we do for life sciences? (in session "Biological membranes, surfaces and interfaces")

KWS-2 – the Extended Q-Range High-Flux SANS Diffractometer for Life Sciences (in session "Poster Session")

Life Science at the SNS Second Target Station (in session "Neutron and complementary methods in biology")

Life sciences with neutrons at IBR-2 reactor (in session "Life Sciences at Russian Neutron Sources")

Linking cell uptake to self-assembled block co-polymer nanoparticle morphology – small angle scattering studies (in session "Drug design and delivery")

Linking genes and membrane lipid composition to insights of the antifungal mechanism of Amphotericin B provided by neutron reflectometry (in session "Poster Session")

LP3 and DEMAX (in session "Poster Session")

Macromolecular Neutron Diffraction at the Heinz Maier-Leibnitz Zentrum (in session "Poster Session")

Mechanical plasticity of the ECM directs branch elongation in human mammary gland organoids (in session "Neutron and complementary methods in biology")

Mechanism of disaccharide-induced protein stabilization from neutron scattering and modeling (in session "Poster Session")

Mechanisms of action for the supramolecular drugs: neutron study (in session "Poster Session")

Modelling the collective dynamics of membrane multilayers and complex membranes (in session "Biological membranes, surfaces and interfaces")

Molecular bases of proteome adaptation to High Pressure in extremophilic Archaea (in session "Poster Session")

Monitoring in vitro human digestion of model food, a plant protein gel, using SANS" (in session "Poster Session")

Mucin thin layers on top of model membranes: a model environment for delivery (in session "Poster Session")

Nanoscale morphology of thermoresponsive double hydrophilic block copolymers in aqueous solutions: impact of block length asymmetry and temperature effects (in session "Drug design and delivery")

Neutron capture produced radioisotopes for diagnostics and therapy - opportunities and challenges. (in session "Drug design and delivery")

Neutron crystal structure analysis of green fluorescent protein (in session "Poster Session")

Neutron crystallography in the fight against COVID-19: Drug Design Targeting SARS-CoV-2 Main Protease (in session "Neutrons in the fight against virus diseases")

Neutron Crystallography of the carbon fixing enzyme Rubisco (in session "Protein structure, function and dynamics")

Neutron Diffractometer for Protein Crystallography at Cold Neutron Beam Line of JRR-3 (in session "Poster Session")

Neutron Scattering Experiments and Multi-Scale Simulations Reveal Dynamical Properties of the Bacterial Cytoplasm Near Cell-Death Temperature (in session "Protein structure, function and dynamics")

Neutron Scattering Experiments Under (in-situ) Illumination (in session "Biological processes")

Neutron structures of Leishmania mexicana triosephosphate isomerase complexes with reaction intermediate mimics shed light on the proton shuttling steps (in session "Protein structure, function and dynamics")

Neutrons reveal (some of) the secrets of heme peroxidases (in session "Protein structure, function and dynamics")

New insights into the interaction of Class II dihydroorotate dehydrogenases with ubiquinone in lipid bilayers as a function of lipid composition (in session "Biological membranes, surfaces and interfaces")

Not just a fluidifying effect: omega-3 phospholipids induce formation of non-lamellar structures in biomembrane (in session "Biological membranes, surfaces and interfaces")

OBSERVING THE CONFORMATIONAL CHANGES OF HUMAN LACTOFERRIN USING SMALL ANGLE NEUTRON SCATTERING (in session "Poster Session")

ON THE INTERACTIONS BETWEEN LACTOFERRIN AND β-LACTOGLOBULIN: A SMALL-ANGLE NEUTRON SCATTERING STUDY (in session "Poster Session")

Organisation and dynamics of hemoglobin within mammalian red blood cells studied with neutron scattering (in session "Poster Session")

Phytochrome function: structural changes and protonation dynamics (in session "Biological processes")

Protein and water dynamics at the atomic level (in session "Poster Session")

Protein Dynamics in Complex Environments (in session "Biological membranes, surfaces and interfaces")

Protein short-time diffusion in polydisperse crowding (in session "Protein structure, function and dynamics")

Quantum cascade laser-based infrared spectrometer combined with small angle neutron scattering for life science applications (in session "Poster Session")

Relationship between the protonation state of the substrate and the absorption spectrum in a mutant of the enzyme that synthesizes a photosynthetic pigment (in session "Poster Session")

Retrieving Myelin/Nerve Fibers in a Brain Section by Small Angle Scattering (in session "Neutron and complementary methods in biology")

Small-angle Neutron Scattering Studies of the Replicase Cofactor Nsp7/8 Complex from SARS-CoV-2 (in session "Neutrons in the fight against virus diseases")

Strong Adverse Contribution of Conformational Dynamics to Streptavidin−Biotin Binding (in session "Protein structure, function and dynamics")

Structural characterization of mRNA - lipid nanoparticle upon pH changes: a SANS study (in session "Drug design and delivery")

Structural dynamics of substrate processing by the PAN-proteasome complex studied by TR-SANS (in session "Protein structure, function and dynamics")

Structural Investigation of Lipid Nanoparticles is key for Successful mRNA Delivery (in session "Drug design and delivery")

Structure of SARS-CoV-2 papain-like protease PLpro reveals a framework for antiviral inhibitor design (in session "Neutrons in the fight against virus diseases")

Studies of the localization of small molecules in self-assembled lamellae structures by neutron diffraction and molecular deuteration (in session "Poster Session")

Temperature-induced reorganization of influenza A nucleoprotein complex (in session "Protein structure, function and dynamics")

Temperature-induced structural changes of PNIPAM- from milliseconds to minutes (in session "Poster Session")

The direct geometry cold chopper spectrometer TOFTOF (in session "Poster Session")

The impact of specific drug molecules on lipid bilayers (in session "Poster Session")

The Phase Behaviour of the Myelin Basic Protein (in session "Poster Session")

The structure of KRas at the membrane – simulation and experiment. (in session "Biological membranes, surfaces and interfaces")

Towards time-resolved protein dynamics on nanoscopic scales (in session "Protein structure, function and dynamics")

Translocation of non-ionic synthetic polymers through lipid membranes (in session "Biological membranes, surfaces and interfaces")

Treating cancer with neutrons – Options for Boron Neutron Capture Therapy (in session "Drug design and delivery")

Understanding the reaction mechanism of chlorite dismutase: Characterizing protonation states of turnover-associated amino acid residues using neutron cryo-crystallography (in session "Poster Session")

X-ray and Neutron Small Angle Scattering study of the non structural proteins nsp10 and nsp14 from SARS-CoV-2 (in session "Poster Session")

XFEL and Neutron Diffraction Studies allow Determination of the Binding Environment of an Iron Binding Protein (in session "Neutron and complementary methods in biology")

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Events scheduled on*

08/06/2021

09/06/2021

10/06/2021

11/06/2021

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