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Jun 8 – 11, 2021 Online only
Europe/Berlin timezone
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Changes in chromatin organization induced by macromolecules and protein complexes as a possible mechanism for epigenetic regulation

Jun 10, 2021, 9:50 AM
Talk Biological processes Biological processes


Dmitry Lebedev (Petersburg Nuclear Physics Institute)


An important question in the study of chromatin packing is to identify the functional significance of its structure and dynamics. The integral properties of chromatin packing as a polymer chain are extremely important for understanding the mechanisms of interaction between distant chromatin regions, the formation of loops, and, ultimately, the formation and dynamics of topologically associated chromatin domains - genome regions associated in space and having similar characteristics of transcriptional activity. The self-organization and evolution of such domains occurs under the influence of a complex of biochemical (post-translational modification of histone proteins, nucleosome dynamics, interaction of chromatin with specific nuclear proteins), and chemical (charge interactions, macromolecular crowding) factors.
Organization of genetic material in eukaryotes exhibit two-phase fractal property of chromatin during interphase, variability in its structure parameters in a number of cell types, and strong effect of macromolecular crowding on both large-scale hierarchy and small-scale nucleosome arrangements, thus providing the experimental basis for the studies chromatin organization throughout its structural hierarchy. Under certain conditions, the chromatin structure as observed by SANS can be influenced by non-nuclear proteins and protein complexes. These changes may manifest an important element in epigenetic regulation mechanisms.

Primary authors

Dmitry Lebedev (Petersburg Nuclear Physics Institute) Yana Zabrodskaya (Petersburg Nuclear Physics Institute) Alexey Shvetsov (PNPI NRCKI) Vitaliy Pipich Dr Alexander Kuklin (JINR, Dubna, Russia, Moscow Institute of Physics and Technology (State University)) Vladimir Egorov (Petersburg Nuclear Physics Institute) Dr Vladimir Isaev-Ivanov (Petersburg Nuclear Physics Institute)

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