Speaker
Henrich Frielinghaus
(JCNS)
Description
We have investigated the impact of the drugs benzocaine and propanolol on a lipid bilayer formed by L-alpha-phosphatidylcholine. The methods used were neutron reflectivity, grazing incidence small angle neutron scattering, small and ultra small angle neutron scattering. On the one hand, we observed a membrane stiffening and a stalk formation for benzocaine. On the other hand, disordered bilayers (lamellar powders) and highly curved structures were found in the presence of propranolol. In this way we hope to explain diseases when high doses of drugs are applied to humans, and what mechanisms could underlie in general when drugs are applied at normal doses.
Primary authors
Henrich Frielinghaus
(JCNS)
Gaetano Mangiapia
(German Engineering Materials Science Centre (GEMS) am Heinz Maier-Leibnitz Zentrum (MLZ))
Manuchar Gvaramia
(University of Geneva)
Alexandros Koutsioumpas
(JCNS)
Olaf Soltwedel
Dr
Jose Teixeira
(LLB Saclay)
