Conveners
Drug design and delivery
- Luigi Paduano (Department of Chemical Sciences, University of Naples "Federico II")
Drug design and delivery
- Olaf Holderer
In tandem with cell studies we have used SAXS and SANS to link nanoparticle structure and its relationship to drug content to provide new strategies for drug delivery nanoparticles as well provide insight into outstanding questions about the entry of particles into cells. Through carefully controlled polymerisation reactions self-assembled block co-polymers offer exquisite control over...
Double hydrophilic block copolymers can self-assemble in water, leading to scaffolds with strong potential in favor of controlled encapsulation of pharmaceutics. We recently demonstrated that thermoresponsive double hydrophilic poly(N-isopropylacrylamide)-block-poly(oligo ethylene glycol methyl ether acrylate) (PNIPAM-b-POEGA) block copolymer self-assemblies in water can successfully...
Radioisotopes are an indispensable tool for diagnostics and therapy in nuclear medicine. As a rule of thumb, proton rich isotopes are most efficiently produced by accelerators, whereas neutron rich isotopes are more efficiently produced by neutron capture reactions. Here, we will focus on the latter process. Inherent to the purpose of nuclear medicine, most of these isotopes are short-lived...
Therapeutic treatments based on the production of proteins by delivering messenger RNA (mRNA) represent a versatile approach. Lipid nanoparticles (LNPs) are promising vehicles for mRNA delivery and are formed by a cationic ionizable lipid (CIL), DSPC, cholesterol (Chol) and a pegylated (PEG) lipid. Even though some LNPs for small interference RNA (siRNA) delivery were recently FDA approved,...
Lipid nanoparticles (LNPs) constituted by a cationic ionizable lipid and helper lipids as cholesterol, phospholipids and poly(ethylene glycol) lipid as stabilizer have made mRNA therapeutics a reality. 2 mRNA-based vaccines against SARS-CoV-2 have received emergency authorization by many regulatory agencies using LNPs as delivery vehicle. We investigated the structure of mRNA-containing LNPs...
Despite all advances in cancer treatment, there are still clinical situations in which a locoregional tumor is fatal. More efficient local therapies are mandatory. Boron Neutron Capture Therapy (BNCT) has the potential of such a modality to overcome radiation resistance in certain tumors or to re-irradiate local recurrences after high-dose radiotherapy.
BNCT is based on the 10B(n,α)7Li...
