Speaker
Description
Magnetic nanoparticles (MNPs) offer a promising avenue for magnetic hyperthermia, a cancer therapy where MNPs are introduced into tumors and then heated with an external magnetic field to destroy cancer cells. For this clinical application to be safe and effective, it's critical to optimize the magnetic field parameters and the heating power. Since safety concerns limit the maximum applied magnetic field amplitude and frequency, improving heating power can be achieved mostly by optimizing the MNP structure itself. An ideal tool for characterising such MNPs is small angle neutron scattering (SANS). Our ERUM-Pro HYMN project aims to develop a novel, unified experimental and computational toolbox for in-situ magnetic hyperthermia experiments under clinical conditions, utilising SANS. This will be achieved by developing two custom-made setups: one AC field generator for operation at the beamline (up to 20 mT at 50-1000 kHz at the sample position) and an accompanying AC Susceptometer, for sample precharacterisation. We also present the progress on the design of these setups and first calibration measurements.
