Structural investigation on PTX-loaded poly(2-oxazoline) molecular brushes

15 May 2019, 19:00
3h
Institute of Advanced Study (TUM Campus Garching)

Institute of Advanced Study

TUM Campus Garching

Lichtenbergstraße 2a, 85748 Garching

Speaker

Jia-Jhen Kang (Technical University of Munich)

Description

Poly(2-alkyl-2-oxazoline) molecular brushes, featuring PMeOx-b-PBuOx side arms, are investigated in aqueous solution. While hydrophobic PBuOx is attached to the backbone, storing the anticancer drug, Paclitaxel, the hydrophilic PMeOx is at the periphery, facilitating transport in water. With small-angle neutron scattering, the structure of the PTX-loaded molecular brushes with different backbone length was revealed, disclosing the effect of the molecular architecture on the drug-loading ability.

Primary authors

Jia-Jhen Kang (Technical University of Munich) Dan Gieseler (Technische Universität Dresden, Fakultät Chemie und Lebensmittelchemie, Professur für Makromolekulare Chemie) Lester Barnsley (Jülich Centre for Neutron Science) Prof. Rainer Jordan (Technische Universität Dresden, Fakultät Chemie und Lebensmittelchemie, Professur für Makromolekulare Chemie) Christine Papadakis (Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie)

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