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May 22 – 25, 2023
Munich
Europe/Berlin timezone

Redefining our understanding of drug loaded polymer micelles using neutron, synthesis and molecular modelling

May 22, 2023, 4:40 PM
20m
Schloss Fürstenried (Munich)

Schloss Fürstenried

Munich

Forst-Kasten-Allee 103 81475 München Germany
Talk Nanomedicine Nanomedicine

Speaker

Robert Luxenhofer (University of Helsinki)

Description

Over the last decades, our understanding of drug loaded micelles was simple. The core dissolves and protects the drugs, the micelle corona ensures stealth properties and ensures colloidal stability. Using a wide variety of analytical tools, including neutron scattering, NMR spectroscopy, synthetic variations and in silico molecular modeling, we have found conclusive evidence that this simplistic view does not reflect experimental realities. Accordingly, we suggest to significantly overhaul our view, models and cartoons of drug loaded to reflect on updated vision, wherein the hydrophilic corona is actively engaged in drug interactions and thereby critical for drug solubilization, biodistribution and therapeutic efficacy.

Primary author

Robert Luxenhofer (University of Helsinki)

Presentation materials

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