Dec 8 – 10, 2020 Online only
Online event
Europe/Berlin timezone

Stimuli-Responsive Micelles from Amphiphilic Diblock Copolymers

Dec 9, 2020, 2:30 PM
3h 30m
Online event

Online event

Speaker

Yanan Li (Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie)

Description

Stimuli-responsive block copolymers self-assemble in aqueous solution and respond to changes of their environment, rendering them useful as smart nanocarriers for drug delivery and gene therapy. In the present project, we investigate responsive micelles formed by PDMAEMA-b-PLMA or PDMAEMA-b-PLMA-b-POEGMA [1,2]. PDMAEMA is a weak cationic polyelectrolyte and responsive to pH, ionic strength and temperature, whereas PLMA is strongly hydrophobic, enabling the delivery of hydrophobic drugs. POEGMA is permanently water-soluble and improves biocompatibility. Dynamic light scattering on PDMAEMA70-b-PLMA39 revealed that, at pD 2.8, self-assembled structures form, whose relatively large size points to vesicle formation. At pD 7.8 and 10.4, additional large aggregates are present up to a certain temperature. Detailed structural information is obtained from small-angle neutron scattering (SANS) at KWS-2 at MLZ, confirming the differences of the micellar structures in acid or alkaline solution.

Primary authors

Yanan Li (Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie) Jia-Jhen Kang (Technical University of Munich) Athanasios Skandalis (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation) Varvara Chrysostomou (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation) Aurel Radulescu (Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science at MLZ) Dr Stergios Pispas (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation) Christine Papadakis (Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie)

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