Dec 8 – 10, 2020 Online only
Online event
Europe/Berlin timezone

Thermal effects on nanoscale morphologies and chemical group vibrations of thermoresponsive double hydrophilic block copolymers in aqueous solutions

Dec 9, 2020, 2:30 PM
3h 30m
Online event

Online event


Dr Apostolos Vagias (FRM2 / TUM)


Thermoresponsive double hydrophilic block copolymers exhibit great interest as model scaffolds for pharmaceutical applications due to their controlled potential in drug encapsulation and release. A thorough elucidation of the nanostructure of the formed self-assemblies and its evolution at different temperatures is mandatory to provide tailored design guidelines in targeted therapeutics. We present a summary on the investigation of the internal morphology for aqueous self-assembled nanostructures of novel double thermoresponsive PNIPAM-b-poly (oligo ethylene glycol methyl ether acrylate) (PNIPAM-b-POEGA) block copolymers by small angle neutron scattering (SANS). Our findings propose a distinct impact of chain-end groups on self-assembled morphologies, as well as on the interchain/intrachain interactions. The lower critical solution temperature (LCST) of these block copolymer solutions defines a transition crossover from hierarchical morphologies to well-defined nanoscale morphologies at temperatures above the LCST. Our scattering results are complemented by Fourier-Transform Infrared (FTIR) Spectroscopy. The combined FTIR and SANS data reveal that temperature-dependent vibrations of chemical moieties do not necessarily correlate to the analogous structural transitions at the nanoscale. Thereby, our study provides important insights into the morphology related to these thermoresponsive double hydrophilic block copolymer scaffolds for pharmaceutical applications.

Primary authors

Dr Apostolos Vagias (FRM2 / TUM) Dr Aristeidis Papagiannopoulos (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation) Mrs Despoina Giaouzi (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation) Lucas P. Kreuzer (TU München, Physik Department, E13) Sebastian Busch (GEMS at MLZ, HZG) Peter Müller-Buschbaum (TU München, Physik-Department, LS Funktionelle Materialien) Dr Stergios Pispas (Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation)

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