The recent success of messenger RNA (mRNA) nanoparticles for vaccination against Covid-19 has highlighted the great potential of nanoparticulate pharmaceutical products for application in a wide variety of indications, including cancer.
Nanoparticles can be formed from different materials, including lipids (liposomes, lipid nanoparticles) polymers, as well as inorganic materials or hybrid...
Translocation of macromolecules through the cellular membrane mostly occurs via pore formation involving a strong local disruption of the membrane, or via endocytosis, which requires the second translocation step – endosomal escape. Passive translocation of macromolecules is highly desirable for biomedical applications but rare due to their size, complexity, polarity, or other factors. We...
Over the last decades, our understanding of drug loaded micelles was simple. The core dissolves and protects the drugs, the micelle corona ensures stealth properties and ensures colloidal stability. Using a wide variety of analytical tools, including neutron scattering, NMR spectroscopy, synthetic variations and in silico molecular modeling, we have found conclusive evidence that this...
Effective therapeutics may be enabled by drug targeted delivery and optimized cellular penetration. Ideally drugs are specifically directed to the site of action to minimize side effects and optimize the therapeutic action. Off target drug delivery decreases the therapeutic index of a particular pharmacological treatment, particularly in the case of cyto-toxic drugs. In this work we have...
Magnesium (Mg)-based implants are in the focus for orthopedic applications, due to their biocompatibility and biodegradability. Depending on the alloy, the degradation behavior and integration into the bone will differ. To elucidate this complex interplay which affects all hierarchical levels of bone, synchrotron radiation-based scattering and imaging techniques are used. Specifically, we have...
