Conveners
DN2020: Life Science/ Biology: Part 1/1
- Frank Schreiber (Uni Tübingen, Angewandte Physik)
Disordered regions as found in intrinsically disordered proteins (IDP) or during protein folding define response time to stimuli and protein folding times. Neutron Spinecho Spectroscopy is a powerful tool to access directly collective motions of the unfolded chain to observe conformational relaxations. During thermal unfolding of native Ribonuclease A we examine structure and dynamics of the...
Following dynamics during kinetically changing samples is a major challenge. With recent developments of analysis frameworks, accessing the short-time self-diffusive properties of protein solutions by measuring specific energy transfers (FWS) via neutron backscattering, kinetically changing samples can be investigated. More detailed information (internal dynamics and immobile fraction of the...
A major component of the saltatory nerve signal conduction is the multilamellar myelin membrane around axons. In demyelinating diseases like multiple sclerosis, this membrane is damaged which leads to severe problems in nerve conduction. In literature different values for the lipid composition of healthy myelin sheath and myelin in the condition of experimental autoimmune encephalomyelitis -...
Macromolecular crowding, i.e. the presence of macromolecules at high volume fractions, affects reaction rates and transport processes in the cell. For reliable quantitative models of cellular pathways, the mobility of individual proteins is thus a key information. Often, the protein mobility is modeled by the self-diffusion of colloidal systems. The underlying assumption that neither the shape...
