Conveners
Proteins & Peptides seen by Neutrons
- Tommy Nylander (Lund University)
- Michaela Zamponi (Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science at Heinz Maier-Leibnitz Zentrum)
Temperature variations have a big impact on the bacterial metabolism and death, yet an exhaustive molecular picture of these processes is still missing. For instance, whether the thermal death is determined by the deterioration of the whole or a specific part of the proteome is hotly debated. In our work, by monitoring the proteome dynamics of E. coli we show that only a minor fraction of the...
Sickle cell disease (SCD) is a genetic blood disorder, inducing severe anemia. It results from the polymerization of the oxygen-carrying protein hemoglobin found in red blood cells (RBC), which leads to a deformation of the cells to rigid, sickle-like shape under certain circumstances that will obstruct capillaries vessels, and will ultimately induce the disease of different organs. The...
Protein dynamics play a vital role in biology. Quasi elastic neutron scattering is an ideal method to access these dynamics. Normally data analysis is performed based on the assumption that the scattering spectrum is incoherent. In order to be observe the full range of protein dynamics it is necessary to perform the experiments in solution. This solution is usually a fully deuterated buffer,...
Small angle neutron scattering (SANS) is a non-ionizing and non-destructive statistical probe of structure. When applied to actively metabolizing cells it can provide a perspective on structural changes associated with cell physiology. Here we report on the application of SANS to understand environmentally induced physiological changes of corals. Corals bleach under a number of stresses, one...
